The player has purchased every slot in one of the Plasmid or Tonic tracks

Purchased every slot in all four Plasmid and Tonic tracks

The player has purchased one slot in any Plasmid or Tonic track

The player has acquired at least one weapon upgrade

The player has fully upgraded one weapon

The player has fully upgraded two weapons

The player has fully upgraded three weapons

Fully upgrade four weapons

Fully upgrade five weapons

Acquire all upgrades for all weapons

The player has fully researched the Thuggish Splicer

The player has fully researched the Leadhead Splicer

The player has fully researched the Spider Splicer

Fully research the Houdini Splicer

Fully research the Nitro Splicer

Fully research the Rosie

Fully research the Bouncer

Fully research the Little Sister

Take at least one photo in every research group

Max out all possible research

The player has taken a Research Photo of the highest grade

The player has taken at least one Research Photo of a Splicer

The player has performed at least one successful hack

The player has successfully hacked a security bot

The player has successfully hacked a security camera

The player has successfully hacked a turret

The player has successfully hacked a vending machine

The player has successfully hacked a safe

The player has successfully completed 50 hacks

The player has successfully invented at least one item

Successfully invent at least 100 items

The player has successfully invented all possible ammo types

Collect or Invent 58 Tonics in the Physical, Engineering and Combat tracks

Find every audio diary

The player has completed the game on the Hard difficulty setting

The player has either Harvested or Rescued every possible Little Sister

Hit the jackpot at a slot machine